A Hepatoprotective Effect of Extract Ethanol Gynura procumbens on Liver Injury Induced by Toxic Dose of Paracetamol

Gynura procumbens is a plant that contains flavonoid compounds as antioxidants and has hepatoprotective effect. A hepatoprotector compound can protect the liver from damage. One way to determine function measure enzyme activity of Serum Glutamic Oxaloacetic Transaminase (SGOT) Pyruvic (SGPT). This study aimed effect extract ethanol on induced by paracetamol toxic dose. used 20 white male rats divided into five groups: positive control group, negative (NaCMC 1%), dose 2.400mg/kg bw). EDSNY 100 mg/kg bw, 200 300 bw + 2.400 paracetamolThe rat blood samples were taken through lateral vein, then SGOT SGPT measured before, after 4 days, 6th day induction. The results showed significantly reduced levels in mice at bw. However, leaves could not reduce rats. From histopathological results, it was evident both low, medium, high doses had been able improve damage paracetamol. appeared number areas necrosis degeneration hepatocytes compared group. Based study's against an increase SGPT. Still, hadn't shown best caused too much